- #The strange story about people who have blue eyes skin#
- #The strange story about people who have blue eyes full#
Congenital "Horner's syndrome" is not a genetic syndrome, but a group of findings due to birth injury or intrauterine brain injury involving the sympathetic nervous system innervation to one eye.Affected people sometimes have heterochromia iridis.
#The strange story about people who have blue eyes skin#
People with this condition have patches of depigmented skin on their head and trunk, as well as on their eyebrows, eyelids, eyelashes, and hair. "Piebaldism" is similar to Waardenburg syndrome but is unassociated with deafness.Waardenburg syndrome, an autosomal dominant genetic condition that can cause hearing loss and changes in coloring of the hair, skin, and eyes.The lighter iris may be differently colored throughout or only in part.Ĭongenital syndromes which may be characterized by heterochromia iridis include: The lighter eye usually shows some loss of iris and therefore is regarded as the affected eye. This is simply called congenital heterochromia iridis. Most cases of heterochromia at birth are genetic and unassociated with any other ocular or systemic abnormality. If another disorder is suspected, diagnostic tests, such as blood tests or chromosome studies, may be done to confirm the diagnosis. An infant with heterochromia should be examined by both a pediatrician and an ophthalmologist for other possible problems. Environmental or acquired factors can alter these inherited traits. Congenital heterochromia may be familial and is inherited as an autosomal dominant trait. The genetics of eye color determination involves at least eight different genes, with inherited eye color being based on various combinations of gene expression. Heterochromia present at or shortly after birth is usually hereditary or due to intrauterine disease or injury. Sometimes one eye may change color following certain diseases or injuries.
Other cases are acquired and caused by a disease or due to an injury. Most cases of heterochromia are hereditary, and these may be associated with a congenital syndrome. Heterochromia is classified primarily by its time of onset as either genetic (congenital, present at or shortly after birth) or acquired. Parry-Romberg syndrome is also accompanied by neurological abnormalities including seizures and episodes of severe facial pain (trigeminal neuralgia). In addition, the skin overlying affected areas may become darkly pigmented (hyperpigmentation) with, in some cases, areas of hyperpigmentation and patches of unpigmented skin (vitiligo). The eye and cheek of the affected side may become sunken and facial hair may turn white and fall out (alopecia). The deterioration may also affect the tongue, the soft and fleshy part of the roof of the mouth, and the gums. Initial facial changes usually involve the tissues above the upper jaw (maxilla) or between the nose and the upper corner of the lip (nasolabial fold) and subsequently progress to the angle of the mouth, areas around the eye, the brow, the ear, and the neck. It is more common in females than in males. Parry-Romberg syndrome is a rare disorder characterized by slowly progressive deterioration (atrophy) of the skin and soft tissues of half of the face (hemifacial atrophy), usually the left side.
One Cause of Heterochromia Iridis Parry-Romberg Syndrome Eye color is determined primarily by the concentration and distribution of melanin within the iris tissues. In heterochromia, the affected eye may be hyperpigmented (darker or hyperchromic) or hypopigmented (lighter or hypochromic). Normally, the two irises of an individual are of the same color. Other genes may determine the pattern and placement of pigment in the iris, thereby accounting for solid brown as opposed to rays of color.
#The strange story about people who have blue eyes full#
These genes interact to provide the full constellation of colors. Although eye color is inherited, the inheritance pattern is complex, with interaction of more than one gene. Brown eyes have large amounts of melanin pigment deposits, and blue eyes have a lack of melanin. Iris color is the result of the pigment that is present in the iris. Heterochromia iridis is to be differentiated from heterochromia (difference in color) iridum (within the iris of one eye). The iris is the tissue of the eye that surrounds the pupil and imparts a color, whether green, blue, brown, hazel, grey, or other, to the eye. Heterochromia iridis is a condition in which the iris in one eye has a different color than the iris of the other eye.